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| Publication Abstract Display | | Type: Poster | | Title: National NeuroAIDS Tissue Consortium: Enabling studies on HAND neuropathogenesis. | | Authors: Grant I, Sherman S, Morgello S, Singer E, Fox H, Gelman B, Brandt D | | Date: 07-20-2014 | | Abstract:Background: To understand the mechanisms of HIV neuropathogenesis NIH established brain banks at 4 U.S. universities to enable investigators to link brain tissue findings to various clinical parameters. Here we describe the resource, and rates of HAND in persons dying with HIV.
Methods: The National NeuroAIDS Tissue Consortium (NNTC) collects and distributes CNS and systemic samples from HIV sero-positive and sero-negative individuals who have been well-characterized in life. Tissues are provided as paraffin embedded, formalin fixed, or frozen blocks. Plasma, serum, and PBMCs are also available. Tissue and/or associated data are available to qualified investigators at no charge beyond shipping expenses.
New web resources available for users include:
· Public use data set with documentation
· Query tool with download utility
· Experimental results from previous NNTC studies
· Bioinformatics resources at University of Nebraska
Tissue Bank Holdings:
Fixed Brain Specimens:
· 762 HIV sero-positive
· 215 HIV sero-negative
HIV sero-positive brains:
· 46% have antemortem plasma
· 35% have antemortem serum
· 27% have antemortem CSF
· 456 have neurocognitive assessment prior to death
Longitudinal Cohort:
Enrolled:
· 2149 sero-positive
· 88 sero-negative cases
HIV sero-positive cases:
· 542 are active
· 538 are deceased with autopsy
· 256 are deceased without autopsy
· 813 are inactive
Results: 1875 have a baseline neurocognitive diagnosis:
· 20% normal
· 14% asymptomatic neurocognitive impairment (ANI)
· 21% mild neurocognitive disorder (MND)
· 12% HIV associated dementia (HAD)
· 33% neuropsychological impairment due to other causes
NNTC Impact:
13,584 specimens of various tissues and fluids have been distributed between 1999 and 2014.
Scientific contributions resulting from the NNTC resources are significant, with close to 400 publications resulting from the use of the NNTC resources. The resource was important in numerous investigators securing funded research applications.
Conclusions: The NNTC has become an invaluable resource, expanding the field of NeuroAIDS research by making available unique neurologically focused tissue linked to antemortem clinical data. More information about the NNTC, including user information and cohort description, is available at www.nntc.org. |
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