| Publication Abstract Display | | Type: Published Manuscript | | Title: Verbal memory performance of patients with Human Immunodeficiency Virus infection: evidence of subcortical dysfunction. | | Authors: Peavy G, Jacobs D, Salmon DP, Butters N, Delis DC, Taylor M, Massman P, Stout JC, Heindel WC, Kirson D, Atkinson JH, Chandler JL, Grant I, and the HNRC Group | | Collective: The HNRC Group | | Year: 1994 | | Publication: Journal of Clinical and Experimental Neuropsychology : official journal of the International Neuropsychological Society | | Volume: 16 Issue: 4 Pages: 508-23 | | Abstract:In the present study, the California Verbal Learning Test (CVLT) was administered to symptomatic HIV+ (n = 31), asymptomatic HIV+ (n = 94), and HIV-normal control (HIV-NC) (n = 40) subjects to assess the prevalence and nature of their verbal memory deficits. Symptomatic HIV+ subjects were significantly impaired relative to HIV-control subjects on CVLT measures of acquisition and retention, and were significantly less likely than control subjects to use a semantic clustering strategy to support recall. The performance of the asymptomatic HIV+ subjects fell between those of the symptomatic HIV+ subjects and HIV-controls on almost every CVLT measure. A linear discriminant function analysis (DFA) was used to compare the performances of these three groups to Alzheimer`s disease (AD). Huntington`s disease (HD), and normal control (NC) subjects on three CVLT measures, including total recall over five learning trials, intrusion errors, and a derived score of delayed recognition discriminability minus the final learning trial. Significant differences were found between the number of symptomatic HIV+ subjects classified as HD (32%), AD (3%), and normal (65%), the number of asymptomatic HIV+ subjects classified as HD (16%), AD (1%), and normal (83%), and the number of HIV-NC subjects classified as HD (2%), AD (0%), and normal (98%). The profile of verbal memory deficits exhibited by the subgroup of impaired HIV+ subjects was similar to that of patients with HD, a prototypical subcortical dementia, and different from that of patients with AD, a prototypical cortical dementia. This finding is consistent with reports of the predominance of subcortical neuropathological changes associated with HIV infection. |
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