| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Reduction in cortical IMP-SPET tracer uptake with recent cigarette consumption in a young group of healthy males. |
| Authors: Rourke SB, Dupont RM, Grant I, Lehr PP, Lamoureux G, Halpern S, Yeung DW |
| Collective: San Diego HIV Neurobehavioral Research Center |
| Year: 1997 |
| Publication: European Journal of Nuclear Medicine |
| Volume: 24 Issue: 4 Pages: 422-7 |
| Abstract:Functional brain imaging techniques are being used increasingly to infer disturbances in brain function in various neuropsychiatric disorders, but the specificity of such findings is not always clear. We retrospectively examined the effects of one possible confound - cigarette smoking - on cortical uptake of iodine-123 iodoamphetamine (IMP) using single-photon emission tomographic imaging in a young (mean age=35 years) healthy group of male controls divided according to their smoking history. Subjects who had never smoked (n=17), or those with a history of smoking but no recent smoking (n=8), had equivalent and significantly higher mean cortical uptake of IMP than subjects with a history of smoking and who were current smokers (n=8). There were no differences in the cortical distribution of IMP. Our results indicate that cigarette smoking has an acute effect on global cerebral blood flow. This potential confound must be considered before abnormalities in cortical tracer uptake are attributed to some neuropsychiatric disorder of interest. |