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Publication Abstract Display
Type: Published Abstract
Title: Cytochrome P450 2D6 phenotype and methamphetamine-associated cognitive impairment.
Authors: Cherner M, Bousman C, Barron D, Letendre S, Everall I, Heaton R, Atkinson J, Grant I
Year: 2008
Publication: Journal of the International Neuropsychological Society
Volume: 14 Issue: Suppl. 2 Pages: 130
Abstract:Methamphetamine(meth) dependence has been associated with Neuropsychological impairments that are often unrelated to meth exposure parameters such as length of abstinence, lifetime consumption, chronicity, mode of delivery,etc.,suggesting individual differences in vulnerability to the neurotoxic effects of meth. We examined whether vulnerability to cog- nitive impairmentis linked to polymorphisms of liver enzyme cytochrome P4502D6(CYP2D6), which is responsible for oxidative metabolism of meth.

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