| Abstract:When
comparing
brain
samples
from
four
brain
regions,
levels
of
mtDNA
and
mitochondrial
injury
were
highest
in
the
white
matter
of
the
middle
frontal
gyrus
(
Figure
2
)
.
Higher
abundance
of
the
common
deletion
was
associated
with
increasing
age
(
Figure
3
)
.
MtDNA
damage
was
also
associated
with
better
neurocognitive
function
only
in
METH
users
(
Table
2
)
.
METH
use
appears
to
have
a
protective
effect
on
mitochondrial
injury
.
METH
use
has
been
shown
to
increase
autophagy
and
mediate
neuroprotection
at
low
doses
. |