return to TMARC
| Publication Abstract Display | | Type: Published Abstract | | Title: Cognitive, psychiatric, and medical predictors of relapse in HIV+ methamphetamine abusers. | | Authors: Rippeth J, Carey CL, Woods SP, Heaton RK, Grant I, and the HNRC Group | | Year: 2004 | | Publication: Journal of the International Neuropsychological Society | | Volume: 10 Issue: Suppl S1 Pages: 20 | | Abstract:Methamphetamine (METH) abuse and HIV-1 infection are independently
asMria~ with ne~aychological (NP) deficitB, with ~t reaearch indicating
d1e8eri Ik factors confer additive deleterious NP effects. Thi8 study
e.umined p~dicton of relapse for HIV + METH abuaers. The sample~-
listed of 34 HIV + participantB who met lifetime DSM - IV criteria for METH
depend~ and abuse! depen~ criteria within 18 month. of the baseline
evaluation. ParticipantB ~ported abstinence from METH a minimum
of 21 days prior to evaluation. A comprehensive NP battery with demographicallY
oo~ T-1COresw u .tJminiRte.-red; 65% of the &le
exhibiud global NP impainnent, with learning, delayed ~cal1, and motor
domaioa exhibiting the higbeatimpainn ent rates. Relapee wu defined 88
meeting METH abuse!depen~ critaia any time d1UiD8 8 2-year follow-
up period. The overall relapse rate W88 41 %. At baaeIine, reiap&era
did not differ from nonrelapsera for demosrapbics, lifetime ME`m use,
mY dj.eue characteristics, p~valence of global NP impainnent, or rates
of affective or .~ use diaorden. Reiapaen did exhibit higher ratea
ofbaseliDe motnr impainnent and Antisocial PenonaJity ~er (ASPD).
In fact, 71 % of ~ displayed baseline motor imp airment (venua 30%
in nome lapsen ), and 1 00 % we ~ diagnoaed wi th ASP D. Ra tea of NP impairment
in this METI-I dependent sample were substantial; however,
8mOD8 NP domaina, only motor imp airment was significantly .~ated
with relapse. These results also SUMeIt psychianic diaorden (i.e., ASPD)
are &alient predictors of relapse. Clinicians should be cognizant that ASPD
and motor impainnent, which is particularly senJitive to the neurotDxicity
asaociate4 with mv and ME1H, are risk factoR for ~8e, and preventive
interventiom should be targeted appropriately. |
return to publications listing
|