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Publication Abstract Display
Type: Published Manuscript
Title: Lower CSF homovanillic acid relates to higher burden of neuroinflammation and depression in people with HIV disease.
Authors: Saloner R, Cherner M, Grelotti DJ, Paolillo EW, Moore DJ, Heaton RK, Letendre SL, Kumar A, Grant I, Ellis RJ
Year: 2020
Publication: Brain, Behavior, And Immunity
Volume: 90 Issue: Pages: 353-363
Abstract:HIV-related neuroinflammation has been proposed as a catalyst for dopaminergic dysregulation in mesocortical pathways, which may contribute to the pathogenesis of depression. Abnormalities in dopaminergic neurotransmission and depression are common in people with HIV (PWH), however the link between dopamine (DA) and depression in PWH is poorly characterized. This study investigated CSF dopaminergic biomarkers, specifically DA and its metabolite, homovanillic acid (HVA), and examined their relationship with depressive symptoms and CSF neuroinflammatory markers in PWH and HIV-seronegative (HIV-) individuals.

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