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| Publication Abstract Display | | Type: Published Manuscript | | Title: The relationships between HIV-1 Infection, history of methamphetamine use disorder, and soluble biomarkers in blood and cerebrospinal fluid. | | Authors: Walter TJ, Iudicello J, Cookson DR, Franklin D, Tang B, Young JW, Perry W, Ellis R, Heaton RK, Grant I, Minassian A, Letendre S, on behalf of the Translational Methamphetamine AIDS Research Center TMARC | | Year: 2021 | | Publication: Viruses | | Volume: 13 Issue: 7 Pages: 1287 | | Abstract:Methamphetamine (METH) use disorder is highly prevalent among people with HIV (PWH) and is a significant public health problem. HIV and METH use are each associated with immune system dysfunction; however, the combined effects on the immune system are poorly understood. This cross-sectional project measured soluble immune biomarkers in plasma and cerebrospinal fluid (CSF) collected from a control group, people with a history of a METH use disorder (METH+), PWH with no history of METH use disorder (HIV+), and PWH with a history of METH use disorder (HIV+/METH+). HIV, METH, and immune dysfunction can also be associated with affective and cognitive deficits, so we characterized mood and cognition in our participants. Two factor analyses were performed for the plasma and CSF biomarkers. Plasma IL-8, Ccl2, VEGF, and 8-isoprostane loaded onto one factor that was highest in the HIV+/METH+ group ( |
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