Publication Abstract Display
Type: Published Manuscript
Title: Changes in expression of DNA-methyltransferase and cannabinoid receptor MRNAs in blood lymphocytes after acute cannabis smoking.
Authors: Smith RC, Sershen H, Janowsky DS, Lajtha A, Grieco M, Gangoiti JA, Gertsman I, Johnson WS, Marcotte TD, Davis JM
Year: 2022
Publication: Frontiers in Psychiatry
Volume: 13 Issue: Pages: 887700
Abstract:Cannabis use is a component risk factor for the manifestation of schizophrenia. The biological effects of cannabis include effects on epigenetic systems, immunological parameters, in addition to changes in cannabinoid receptors 1 and 2, that may be associated with this risk. However, there has been limited study of the effects of smoked cannabis on these biological effects in human peripheral blood cells. We analyzed the effects of two concentrations of tetrahydrocannabinol (THC) vs. placebo in lymphocytes of a subset of participants who enrolled in a double-blind study of the effects of cannabis on driving performance (outcome not the focus of this study).

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