| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV. |
| Authors: Walter KC, Avalos B, Ford MK, Laird AE, Boustani A, Spencer M, Shu L, Chaillon A, Crescini M, Cookson D, Ellis RJ, Letendre SL, Iudicello J, Fields JA |
| Year: 2025 |
| Publication: Frontiers in Immunology |
| Volume: 16 Issue: Pages: 1634203 |
| Abstract:Human immunodeficiency virus (HIV) infection is often associated with chronic inflammation and cognitive dysfunction in people living with HIV (PWH). The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome plays a crucial role in the secretion of pro-inflammatory cytokines, specifically interleukin (IL)-18 and IL-1β. Cannabis use and certain phytocannabinoids, such as cannabidiol (CBD), may provide therapeutic benefits in conditions associated with chronic inflammation. |