| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Valproic Acid does not affect markers of Human Immunodeficiency Virus disease progression. |
| Authors: Ances BM, Letendre S, Buzzell M, Marquie-Beck J, Lazaretto D, Marcotte TD, Grant I, Ellis RJ, and the HNRC Group |
| Contact: Department of Neurosciences, University of California, San Diego, California, USA. bances@ucsd.edu |
| Year: 2006 |
| Publication: Journal of NeuroVirology |
| Volume: 12 Issue: 5 Pages: 403-6 |
| Abstract:Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention. |
| Funding: NIMH:MH MH 62512 |