| Publication Abstract Display |
| Type: Poster |
| Title: Efavirenz and emtricitabine concentrations consistently exceed wild-type IC50 in cerebrospinal fluid: CHARTER findings. |
| Authors: Best B, Letendre S, Capparelli E, Ellis R, Rossi S, Koopmans P, Grant I, and the CHARTER Group |
| Date: 02-08-2009 |
| Abstract:"Background: Persistent HIV replication subtherapeutic concentrations of antiretrovirals (ARVs) in the nervous system may put patients at risk for HIV-Associated Neurocognitive Disorders (HAND). Emtricitabine (FTC) is commonly used but its concentrations in CSF have not been measured. Concentrations of efavirenz (EFV) in CSF are uncertain since they were detectable in one study (n=10), but undetectable in another (n=11). This study`s objective was to determine concentrations of EFV and FTC in CSF |