| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives. |
| Authors: Anderson A, Schein T, Kalapila A, Lai L, Waldrop-Valverde D, Moore R, Franklin D, Letendre S, Barnum S |
| Year: 2017 |
| Publication: Journal of Neuroimmunology |
| Volume: 311 Issue: Pages: 35-39 |
| Abstract:The soluble membrane attack complex (sMAC) represents the terminal product of the complement cascade. We enrolled 47 HIV+ adults (12 of whom underwent a second visit at least 24weeks after starting therapy) as well as 11 HIV negative controls. At baseline, cerebrospinal fluid (CSF) sMAC was detectable in 27.7% of HIV+ individuals. CSF sMAC correlated with CSF HIV RNA levels and was more likely to be detectable in HIV+ individuals on cART compared to HIV negative controls. In HIV+ participants, there were negative association trends between sMAC and neurocognitive performance but these did not reach statistical significance. |