Publication Abstract Display |
Type: Published Manuscript |
Title: Peripheral inflammation and depressed mood independently predict neurocognitive worsening over 12 years. |
Authors: Ellis RJ, Heaton RK, Tang B, Collier AC, Marra CM, Gelman BB, Morgello S, Clifford DB, Sacktor N, Cookson D, Letendre S |
Year: 2022 |
Publication: Brain, Behavior, & Immunity - Health |
Volume: 21 Issue: Pages: 100437 |
Abstract:Neurocognitive (NC) impairment in people with HIV (PWH) is associated with important adverse outcomes, but no markers exist to predict long-term NC decline. We evaluated depressed mood and markers of persistent inflammation, oxidative stress and altered amyloid processing (all common in PWH) as predictors of NC worsening over 12 years. |