Publication Abstract Display
Type: Published Abstract
Title: Neurochemical markers of cellular integrity predict white matter anisotropy in HIV infection.
Authors: Schweinsburg BC, Jacobus JJ, Taylor MJ, Harrison TB, Theilmann RJ, Woods SP, Letendre S, Ellis RJ, Frank LR, Franklin DR, Heaton R, Grant I, Jernigan TL
Year: 2008
Publication: Journal of the International Neuropsychological Society
Volume: 14 Issue: Suppl. 1 Pages: 243-244
Abstract:"Introduction: Inflammation and neuronal excitotoxicity may represent distinct pathways to HIV-related brain injury; however, these pathways interact at the molecular level. There is reason to believe that the inflammatory changes are tightly coupled to altered axonal metabolism, leading to changes in white matter microstructure. In this study, we explored the relationship between in vivo neurochemical markers of phospholipid metabolism (CHO: choline compounds, increased during inflammation) and axonal metabolism (NAA: N-acetylaspartate, neuronal marker) to determine how they relate to white matter change across major fiber pathways. We predicted that HIV-related inflammation (increased CHO) would moderate the relationship between NAA and fractional anisotropy (FA, an estimate of white matter microstructural integrity).

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