| Publication Abstract Display | | Type: Published Abstract | | Title: Multi-drug resistance-1 gene and Indinavir concentration in cerebrospinal fluid and plasma from HIV-infected individuals. | | Authors: Marquie-Beck J, Ellis R, Buzzell M, Capparelli E, Rought S, Corbeil J, Holland D, de Almeida S, Letendre S, and the HNRC Group | | Year: 2006 | | Publication: 13th Annual Conference on Retroviruses and Opportunistic Infections | | Volume: Session 70 Issue: Pages: 365 | | Abstract:"Background: The multi-drug resistance gene (MDR-1) encodes P-glycoprotein (P-gp). P-gp is expressed on many cells and effluxes its substrates across apical-luminal surfaces, limiting their penetration into certain cells and tissues. P-gp is heavily expressed at the blood-brain and blood-cerebrospinal fluid (CSF) barriers. Many ART, including indinavir (IDV), are substrates for P-gp. MDR-1 knockout mice show substantially higher levels of IDV in brain tissue than do mice with intact MDR-1 genes. This is the first study to evaluate the relationship between IDV concentration in CSF and MDR-1 genotype in humans. |
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