Publication Abstract Display
Type: Published Abstract
Title: Long-term exposure to dideoxynucleoside analogues in the treatment of HIV infection does not result in worsening polyneuropathy signs or symptoms.
Authors: Ellis R, Letendre S, Lonergan J, Marquie-Beck J, Lazzaretto D, Hung C, and the HNRC Group
Year: 2006
Publication: 13th Annual Conference on Retroviruses and Opportunistic Infections
Volume: Session 70 Issue: Pages: 368
Abstract:"BACKGROUND: Because ART regimens containing dideoxynucleosides, such as stavudine (d4T) and didanosine (ddI) (d-drugs) are first-line therapy for HIV in the developing world, there is clinical concern about their long-term toxicities in settings where the ability to monitor complications is limited and other ART options are few. Previous studies show that treatment-limiting, painful neuropathies occur in some patients within weeks-to-months after starting d-drugs. However, long-term risks are not well-characterized. Our objective was to determine the adverse risk to peripheral nerve function of long-term maintenance on d-drugs.

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