Publication Abstract Display
Type: Poster
Title: Validation of a V3-based genetic biomarker of HIV-1 neurovirulence.
Authors: Pillai S, Pasutti W, McCutchan JA, Marra C, Clifford D, Gelman B, Simpson D, McArthur J, Grant I, Wong J
Date: 02-03-2008
Abstract:"Background: Although ART has decreased the incidence of HIV-associated neurocognitive impairment, the prevalence may be rising due to the beneficial effects of ART on the life span of HIV-infected individuals. We previously studied the effects of viral genotype on HIV-1 neurovirulence by analyzing sequences of the HIV-1 env gene from 18 HIV-infected individuals with available neuropsychiatric data. This exploratory analysis revealed that the presence of serine at gp160 position 300 (V3 loop position 5) was strongly associated with impaired neuropsychological performance. Here we rigorously evaluate and validate gp160 N300S as a viral genetic biomarker of neurovirulence, focusing on a separate population of well-characterized HIV-infected individuals.

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