Publication Abstract Display
Type: Poster
Title: Relationship of medication management test-revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV.
Authors: Patton D, Woods SP, Franklin D, Heaton RK, Collier A, Marra C, Clifford D, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I, for the CHARTER Group
Date: 02-02-2011
Abstract:Background: HIV is detrimental to neuropsychological (NP) functioning1, which is in turn associated with diminished medication management capacity (MMC) and poor adherence2-5. Measures of MMC administered in the laboratory are associated with self-reported adherence2 and other aspects of independent living4. There is advocacy for the use of laboratory-based functional measures to compliment NP assessment in order to better understand the impact of HIV on everyday life functioning and facilitate accurate diagnosis of HIV-associated neurocognitive disorders (HAND)4,6. Prior studies have examined the relationships of functional measures to adherence2; however, none have had a sufficiently large cohort to examine the possible unique role that MMC plays in adherence vis-à-vis other known predictors. Conclusions: The MMT-R is a performance-based measure of medication management capacity that is related to several domains of NP functioning, but appears most heavily influenced by education, working memory, learning, and age. Self-reported adherence was not predicted by impaired MMC. This suggests that actual adherence is not necessarily predicted by ability, but that other factors such as motivation and social support likely play a role. Study limitations include lack of objectively verified adherence (e.g., MEMs) and use of a cross-sectional design. Future studies are encouraged to include objective measures of adherence and explore the utility of medication management tasks that more closely reflect current ART regimens.

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