| Publication Abstract Display | | Type: Poster | | Title: Biomarkers of immune activation contribute to patterns of neural injury in HIV-infected patients on stable ART: An in vivo proton MRS study. | | Authors: Letendre S, Harezlak J, Taylor M, Schifitto G, Daar E, Campbell T, Rosario D, Gualtieri L, Yiannoutsos C, Navia B, for the HIV NeuroImaging Consortium | | Date: 02-28-2011 | | Abstract:Summary and Conclusions
In people taking ART, biomarkers reflecting immune activation were associated
with cerebral metabolites in several brain regions
The findings confirm several findings from an independent cohort (Letendre et al,
Journal of Neurovirology, 2011), including the associations between MCP-1 and
NAA/Cr and the presence of beneficial and detrimental relationships
The associations with multiple biomarkers in both plasma and CSF suggests that
HAND is multifactorial
Findings support the hypothesis that the immune activation that can persist
during effective ART can result in neuroinflammation and neuronal injury
These analyses may also identify clinically useful biomarkers that could
classify risk for HIV-associated brain injury
The statistically significant associations with biomarkers in blood are particularly
provocative in this regard, although they accounted for relatively little variance in
cerebral metabolites. |
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