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|Publication Abstract Display|
|Title: Antiretroviral medication non-adherence is associated with deficits in time-based prospective memory: Differential effects of longer ongoing task delay intervals.|
|Authors: Poquette A, Moore DJ, Gouaux B, Morgan EE, Grant I, Woods SP, and the HNRP Group|
|Abstract:Objective: Prospective memory (PM), or remembering to perform a prescribed intention, is an emerging predictor of medication non-adherence. Using McDaniel & Einsteinís (2000) multiprocess framework, the current study examined the differential effects of shorter versus longer ongoing PM task delay intervals (i.e., the time between the encoding and the execution of the intention) as a predictor of antiretroviral (ARV) adherence in HIV infection.
Participants and Method: Participants included 74 HIV-infected individuals who had a high prevalence of psychiatric comorbidities. We tracked ARV medication adherence using an electronic monitoring system, and classified participants as adherent (n = 49) or non-adherent (n = 25) based on openings of >= 90% of prescribed doses. We evaluated short- (2-min) and long- (15-min) delay PM performance with the Memory for Intentions Screening Test (MIST).
Results: An adherence group by delay interval interaction was observed (p = 0.03) such that non-adherent participants had worse performance on the long (d = -0.53), but not short (d = -0.19 ) delay PM scales. The observed long-delay effects were significantly more pronounced on time- (p < .05) versus event- (p > .05) cued PM trials. In a follow-up regression analysis, long-delay time-based PM was an independent predictor of non-adherence, even after considering the influence of demographic, mood state, and general cognitive functioning variables.
Conclusion: These findings suggest that ARV non-adherence may be associated with deficits in strategic cue monitoring over longer PM delays. Interventions to improve antiretroviral medication adherence among persons with HIV-associated PM impairment may be bolstered by increasing the frequency and salience of reminders during the longer delays between prescribed doses.|
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