| Publication Abstract Display | | Type: Published Abstract | | Title: National NeuroAIDS Tissue Consortium: Recent Updates to the Investigator’s Resource. | | Authors: Brandt DK, Sherman S, Fox HS, Gelman B, Grant I, Morgello S, Singer E, Yiannoutsos C | | Year: 2012 | | Publication: Journal of NeuroVirology | | Volume: 18 Issue: Suppl 1 Pages: S17 | | Abstract:The National NeuroAIDS Tissue Consortium was founded with funding from NIMH and NINDS in 1998 to fill the research community’s need for well-characterized tissue and fluids from HIV-infected individuals. The NNTC has since established itself as a valuable resource to the research community by providing quality pre and ante mortem clinical data and tissue to qualified investigators. Since its launch the NNTC has continued to refine its structure and processes in response to the research community’s needs, expanding the scope of available clinical data, implementing a bioinformatics platform, and standardizing data. New resources have been made available via the NNTC website (www.NNTC.org) to assist investigators in mining the NNTC holdings. User feedback is solicited from all users of the NNTC resources for input on NNTC future directions. Currently, the NNTC cohort includes 2331 HIV positive participants, of which 2056 contributed data to the Longitudinal Cohort, 609 are currently in the active cohort, and 782 are deceased with autopsy. In addition, the bank has data and tissue from 237 HIV negative participants. The clinical data collection includes demographics, neuromedical data, neuropsychological assessments, cognitive diagnoses, neuropathologies, PRISM/CIDI, and clinical labs. Recent revisions/additions include improved ARV/concomitant medication histories, comorbidities, and supplemental neuropathologies. The NNTC bioinformatics platform consolidates microarray and other bioinformatics data with clinical annotations to provide an integrated view of the available NNTC resources. Currently SNP and Gene Array data are available for selected cases. The impact of the NNTC is demonstrated by the highly effective and efficient use of high quality tissue and data to as many investigators as possible. The NNTC resource has been used by 203 investigators, with over 315 reported journal publications by external as well as internal investigators. |
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