| Publication Abstract Display | | Type: Published Abstract | | Title: Assessing the lateralization of cingulum bundle injury among recently detoxified alcoholics and its relation to visual versus verbal memory and learning. | | Authors: Alhassoon O, Taylor M, Sorg S, Schweinsburg B, Stephan R, Stricker N, Grant I | | Year: 2013 | | Publication: Archives of Clinical Neuropsychology | | Volume: 28 Issue: 6 Pages: 533 | | Abstract:Objective: The cingulum bundle (CB), a white matter tract in the Papez circuit, has been shown to be affected in recently detoxified alcoholics (RDA), with the right hemisphere more impacted than the left. The current study examines potential lateralization in CB microstructural integrity in relation to verbal versus visual memory and learning among RDA. Method: 15 male RDA (mean age = 51.4 years) from a VA hospital were examined and compared to 15 age and education matched controls. Measures included Expanded Halstead-Reitan Battery story and figure learning, delayed recall loss, and recognition, as well as fractional anisotropy of CB (FACB). Results : Although FACB was found to be lower among RDA in both the right, t(28) = -2.38, p = 0.02, ω2 = 0.14, and the left hemisphere, t(28) = -2.96, p = 0.006, ω2 = 0.21; none of the verbal or visual memory or learning measures correlated with this white matter integrity index. Conclusions: Contrary to previous findings, both the left and the right CB are susceptible to the effect of alcohol. Although the CB is part of the Papez circuit which has recently been found to be involved in memory process, changes in its microstructural integrity does not seem to be correlated with memory or learning in RDA. (VA Merit Review SA-320) |
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