| Publication Abstract Display | | Type: Published Abstract | | Title: Compartmentalized HIV rebound in the CNS after ART interruption. | | Authors: Gianella S, Oliveira M, Scheffler K, Strain M, De La Torre A, Letendre S, Smith D, Kosakovsky Pond S, Ellis R | | Year: 2015 | | Publication: 2015 Annual Conference on Retroviruses and Opportunistic Infections | | Volume: Issue: Pages: | | Abstract:Conclusions: In
most
participants,
HIV
RNA
rebound
occurs
independently
in
blood
and
CSF
after
ART
interruption. Compartmentalization
persists
in
subsequent
time points. Approximately
30%
intermixed
populations. Increased
inflammation
is
associated
with
intermixing
of
viral
population
between
blood
and
CSF. Reservoirs
in
CNS
likely
need
to
be
actively
targeted
as
part
of
eradication
strategies. |
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