| Publication Abstract Display | | Type: Published Abstract | | Title: Low CD4 count related to risk of neuropsychological decline in asymptomatic HIV+ men. | | Authors: Diehr MC, Velin RA, Heaton RK, McCutchan JA, Wallace MR, Grant I, and the HNRC Group | | Year: 1995 | | Publication: Journal of the International Neuropsychological Society | | Volume: 1 Issue: 4 Pages: 346 | | Abstract:Rapid decline in CD4 after seroconversion predicts worse medical outcome; we predicted that those with low CD4 would experience more NP decline. Subjects: 60 HIV+ men in CDC II/III with estimated seropositivity of 3 yr. The group was split at median CD4 (489 cells/mm³) into high-CD4 and low-CD4 subgroups. Method: Expanded Halstead-Reltan Battery was administered at baseline and one-year follow-up. Clinical ratings of NP status and NP change were rendered blindly by RKH. Results: At both visits, the groups differed on Full-Scale and Verbal IQs, but not on age, education, CDC Class, Illness duration, or Performance IQ. At follow-up, the low-CD4 group was worse (p = .01) on global NP functioning. 28% of low-CD4 vs. 10% of high-CD4 were clinically worse on NP status at follow-up (p = .09). Regression analysis confirmed that lower CD4 uniquely predicted follow-up NP after baseline NP was entered. Conclusion: Low CD4 is a risk factor for NP decline in asymptomatic HIV+ men. |
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