| Publication Abstract Display | | Type: Poster | | Title: The human gut microbiome and HIV-associated neurocognitive disorders. | | Authors: Perez-Santiago J, Gianella S, Bharti A, Cookson D, Heaton R, Grant I, Letendre S, Peterson S | | Date: 02-13-2017 | | Abstract:Conclusions:
The gut microbiome, particularly Bacteroidetes and Firmicutes, is associated with HAD (most severe form of HAND) despite the small sample size. Reduction of the Firmicutes/Bacteroidetes ratio has been associated with aging.3
B. caccae, B. obeum, B. ovatus, F. prausnitzii , B. longum, B. uniformis are reduced in HIV infection, all involved in butyrate production, which is associated with higher microbial translocation and immune activation in HIV infection.4
B. longum has been used as a psychobiotic and butyrate has been used as an experimental drug for neurocognitive disorders.5,6
These microbial signatures may be important for identifying individuals with increased risk of developing HAND and may lead to new therapeutic options for individuals with HAND after successful ART. |
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