| Publication Abstract Display | | Type: Published Abstract | | Title: Additive effects of HIV and stimulant dependence as measured by proton magnetic resonance spectroscopy. | | Authors: Taylor MJ, Schweinsburg BC, Alhassoon OM, Videen JS, Grant I, and the HNRC Group | | Year: 1999 | | Publication: Journal of the International Neuropsychological Society | | Volume: 5 Issue: 2 Pages: 155 | | Abstract:HIV-infection and central nervous system stimulant abuse are associated with brain abnormalities, par ticularly in frontostriatal regions. To investigate the combined effects of stimulant dependence and HIV infection on the brain, 7 HIV-infected stimulant dependent individuals (HIV+/STIM+; age = 40.2, SD = 4.3), 5 HIV-infected individuals with no history of stimulant dependence (HIV+/STIM-; age = 40.4, SD = 6.6), 3 seronegative stimulant dependent individuals (HIV-/STIM+; age = 39.8, SD = 6.1) and 5 seronegative individuals with no history of stimulant dependence (HIV-/STIM-; age = 43.3, SD = 8.9) were examined using short echo PRESS proton magnetic resonance spectroscopy (MRS). The metabolites N-acetylaspartate (NAA), choline, myo-inositol, and creatine were measured in the anterior centrum semiovale (ACS), anterior cingulate gyrus (ACG), and caudate nucleus. While lower NAA was found in the ACS and ACG of HIV+/STIM- and HIV-/STIM+, the lowest concentration of NAA was seen in the ACS of HIV+/STIM+. Decreased NAA, a marker of neuronal integrity, in HIV+/STIM+ suggests that stimulant abuse may potentiate HIV-related injury in frontostriatal circuitry.
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