| Publication Abstract Display | | Type: Published Abstract | | Title: Impact of depression on self-reported impairment in HIV and methamphetamine use. | | Authors: Sadek JR, Heaton RK, Woods SP, Rippeth JR, Cherner M, Young C, Lazzaretto D, Grant I, and the HNRC Group | | Year: 2004 | | Publication: Journal of the International Neuropsychological Society | | Volume: 10 Issue: Suppl S1 Pages: 197 | | Abstract:Self-reported cognitive and functional impairment often determines the course of clinical assessment and treatment. We analyzed self-reported cognitive complaints (Patient’s Assessment of Own Functioning Inventory; PAOFI) and instrumental activities of daily living (IADLs) in 94 HIV-infected (HIV+) individuals, 96 individuals with a history of methamphetamine dependence (HIV-Meth+), 88 with both conditions (HIV+Meth+), and 89 controls (HIV-Meth-). The highest rate of neuropsychological (NP) impairment was in HIV+Meth+ (51%) followed by HIV-Meth+ (42%), HIV+Meth- (34%), and HIV-Meth- controls (25%). Higher rates of IADL impairment (p < .05) and worse PAOFI scores (p < .001) were observed in patient groups compared to controls. Depressive symptoms (Beck Depression Inventory, BDI) were also more frequent in patient groups (p <.001) BDI independently predicted PAOFI scores for all four groups (p < .001), but NP impairment also independently predicted PAOFI scores in HIV+Meth+ and HIV-Meth+ (p < .05). A different pattern was observed for IADLs: BDI scores predicted IADL impairment in all groups (p < .05), but NP did not significantly predict IADL impairment for any group (p = .06 for HIV+Meth+, p > .09 for all other groups). Previous studies observed that depression contributes to cognitive complaints. These data extend those findings to IADLs and suggest that NP impairment contributes differently to cognitive vs. IADL complaints. Future research should determine the degree to which depression biases patients’ reporting of everyday functioning, versus actually causes reduced functioning. Still, especially in patients with depression, objective assessment may usefully inform interpretation of their subjective reports. |
return to publications listing
|