| Publication Abstract Display |
| Type: Published Manuscript |
| Title: Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity. |
| Authors: Pendyala G, Trauger SA, Siuzdak G, Fox HS |
| Year: 2011 |
| Publication: AIDS Research and Human Retroviruses |
| Volume: 27 Issue: 2 Pages: 179-182 |
| Abstract:The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals. |