| Publication Abstract Display | | Type: Published Manuscript | | Title: Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CCR5-tropic HIV-1 50% inhibitory concentration. | | Authors: Croteau D, Best BM, Letendre S, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Grant I, and the CHARTER Group | | Year: 2012 | | Publication: AIDS | | Volume: 26 Issue: 7 Pages: 890-893 | | Abstract:To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse phase high performance liquid chromatography with tandem mass spectrometry while ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4 ng/mL. CSF concentrations exceeded the 50% inhibitory concentration (IC50) of wild-type CCR5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF. |
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