| Publication Abstract Display |
| Type: Published Manuscript |
| Title: CB2 cannabinoid agonist enhanced neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. |
| Authors: Avraham HK, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Zvonok A, Masliah E, Avraham S |
| Year: 2014 |
| Publication: British Journal of Pharmacology |
| Volume: 171 Issue: 2 Pages: 468-479 |
| Abstract:HIV-1 glycoprotein Gp120 induces apoptosis in rodent and human neurons in vitro and in vivo. HIV-1/Gp120 is involved in the pathogenesis of HIV-associated dementia (HAD) and inhibits proliferation of adult neural progenitor cells (NPCs) in GFAP/Gp120 transgenic (Tg) mice. Since cannabinoids exert neuroprotective effects in several model systems, we examined the protective effects of CB2 agonist AM1241 on Gp120-mediated insults on neurogenesis. |