| Publication Abstract Display | | Type: Published Manuscript | | Title: Do patients with HIV-associated minor cognitive/motor disorder exhibit a "subcortical" memory profile? Evidence using the California Verbal Learning Test. | | Authors: Delis DC, Peavy G, Heaton R, Butters N, Salmon DP, Taylor M, Stout J, Mehta P, Ryan L, White D, Atkinson JH, Chandler JL, McCutchan JA, Grant I, and the HNRC Group | | Year: 1995 | | Publication: Assessment | | Volume: 2 Issue: Pages: 151-165 | | Abstract:A new diagnostic category for HIV seropositive patients - Minor Cognitive/Motor Disorder (MCMD) - was recently proposed by an AIDS task force sponsored by the American Academy of Neurology. Based on past memory research with HIV+ patients who were diagnosed according the the Centers for Disease Control (CDC) definition of AIDS, we predicted that HIV+ patients who met the new criteria for MCMD would exhibit a "subcortical" memory profile (i.e., they would display primarily a retrieval deficit). This hypothesis was generally supported, but with some exceptions. The HIV+ patients with MCMD were found to have a mild encoding deficit (suggestive of some cortical involvement) superimposed on a pronounced retrieval deficit (suggestive of more extensive subcortical involvement). These findings are consistent with those from a recent neuropathological study indicating an increase in cortical involvement, in addition to predominately subcortical involvement, in more advance stages of the HIV disease process. |
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