| Publication Abstract Display | | Type: Published Manuscript | | Title: Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV. | | Authors: Ellis RJ, Moore DJ, Sundermann EE, Heaton RK, Mehta S, Hulgan T, Samuels D, Fields JA, Letendre SL | | Year: 2020 | | Publication: Neurology, Neuroimmunology & Neuroinflammation | | Volume: 7 Issue: 6 Pages: e902 | | Abstract:To determine whether oxidative stress in virologically suppressed people with HIV (PWH) may contribute to or result from neurodegeneration, we measured 7,8-dihydro-8-oxoguanine (8-oxo-dG), a marker of DNA damage due to oxidative stress, and markers of age-related neurodegeneration, specifically, reduced levels of CSF Aβ-42, and elevated CSF total tau and neurofilament light (NFL). |
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