| Publication Abstract Display | | Type: Published Manuscript | | Title: Early viral brain invasion in iatrogenic Human Immunodeficiency Virus infection. | | Authors: Davis LE, Hjelle BL, Miller VE, Palmer DL, Llewellyn AL, Merlin TL, Young SA, Mills RG, Wachsman W, Wiley CA | | Contact: Neurology Service, Albuquerque Veterans Affairs Medical Center, NM 87108. | | Year: 1992 | | Publication: Neurology | | Volume: 42 Issue: 9 Pages: 1736-9 | | Abstract:We report a 68-year-old man who received an IV inoculation of WBCs for an indium radionuclide scan containing 600 to 700 tissue culture infectious doses of human immunodeficiency virus type 1 (HIV-1) from an HIV-1-infected individual. The recipient immediately received zidovudine, then was switched to dideoxyinosine and interferon-alpha, but died of hepatorenal syndrome and hepatic encephalopathy 15 days later. HIV-1 cultures were positive from the recipient's blood on day 14 but not days 0, 1, and 8. At autopsy, cultures of parietal lobeisolated HIV-1. HIV-1 nucleic acid was present in several brain areas, but not in several other organs, by two independent laboratories using the polymerase chain reaction. The brain showed mild perivascular cuffing and a mild lymphocytic meningitis, but there was no evidence of glial nodules, giant cells, or white matter abnormalities. HIV-1 pg41 viral antigen was seen by immunoperoxidase staining in rare infiltrating cells within perivascular and subpial spaces. Thus, HIV-1 was isolated from brain 15 days after mistaken HIV-1 inoculation and 1 day after virus was first recovered from blood. | | Funding: NINDS:NS NS-25178, NINDS:NS NS-27810, NCI:CA R01 CA55480 | | Keywords: Aged, Autoradiography, Brain, HIV Infections, HIV-1, Humans, Iatrogenic Disease, Infusions, Intravenous, Leukocyte Transfusion, Leukocytes, Male, Polymerase Chain Reaction, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S. |
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