| Publication Abstract Display | | Type: Published Manuscript | | Title: HIV infection and the brain. | | Authors: Gulevich SJ, Wiley CA | | Contact: Department of Neurosciences, University of California, San Diego, La Jolla 92093-0612. | | Year: 1991 | | Publication: AIDS (London, England) | | Volume: 5 Issue: Suppl. 2 Pages: S49-54 | | Abstract:Shortly after the emergence of AIDS in the early 1980s, neurologists recognized that the syndrome frequently included a wide spectrum of rare nervous system infections. It soon became apparent that many of the neurological symptoms and signs of AIDS could not be attributed to an opportunistic infection. With the identification of HIV, evidence indicated that the virus itself could infect and affect the central nervous system (CNS). Subsequent research has concentrated on elucidating the mechanism of neurological injury in HIV encephalitis, and a number of potential explanations have been offered. These include release of neurotoxic substances, such as viral proteins or cytokines, from infected microglial cells, an autoimmune response, and latent infection of glia. Exactly how HIV-1 mediates neurological damage, however, remains uncertain and may be multifactorial. | | Keywords: AIDS Dementia Complex, Forecasting, Humans |
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