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|Publication Abstract Display|
|Title: Time-based prospective memory deficits are associated with psychotropic and ART medication non-adherence among HIV+ individuals with bipolar disorder.|
|Authors: Moore D, Poquette AJ, Gouaux B, Badiee J, Grant I, Woods SP, and the HNRP Group|
|Abstract:Objective: Prospective memory (PM), or remembering to perform a future prescribed intention, is an emerging predictor of medication non-adherence (Woods et al., 2009), and time-based (TB) PM is particularly sensitive to these deficits (Poquette et al., in press). The current study investigated PM as a predictor of psychotropic (PSY) and antiretroviral (ART) medication adherence in a population of HIV+ persons with bipolar disorder (HIV+/BD+).
Participants and Method: Forty-four HIV+/BD+ individuals were enrolled in a text message intervention study aimed to increase medication adherence, and time- and event- based PM performance were assessed with the Memory for Intentions Screening Test. PSY and ART adherence was tracked using an electronic monitoring system and calculated as number of openings/number of prescribed doses.
Results: TB PM was associated with PSY (Spearmanís ρ=0.34, p=0.03) and ART adherence (Spearmanís ρ=0.46, p=0.002). Manic symptoms were also associated with PSY adherence, whereas ART adherence was associated with manic and depressive symptoms, age, and ethnicity (ps<0.10). Neither ART nor PSY adherence was associated with PM recognition, ongoing task scores, HIV disease factors, or global cognitive functioning (ps>0.10). TB PM emerged as the only significant predictor of PSY adherence (p<0.05) in a multivariable model including TB PM, intervention group, and mania scores; TB PM was a significant predictor (p=0.002) of ART adherence in a multivariable model including TB PM, intervention group, mania and depressive scores, age, and ethnicity.
Conclusion: TB PM deficits are related to worse PSY and ART adherence among HIV+/BD+ persons enrolled in an intervention study to improve adherence. Future interventions may need to specifically target TB PM deficits as these appear to be strongly tied to non-adherence even in the context of an intervention targeted at supporting PM difficulties.|
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