Publication Abstract Display | Type: Published Manuscript | Title: Global NeuroAIDS Roundtable. | Authors: Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C | Year: 2013 | Publication: Journal of NeuroVirology | Volume: 19 Issue: 1 Pages: 1-9 | Abstract:In May 2012, the Division of AIDS Research at
the National Institute of Mental Health (NIMH) organized
the Global NeuroAIDS Roundtable in conjunction with
the 11th International Symposium on Neurovirology and the
2012 Conference on HIV in the Nervous System. The meeting
was held in New York, NY, USA and brought together
NIMH-funded investigators who are currently working on
projects related to the neurological complications of AIDS
(NeuroAIDS) in Africa, Asia, Eastern Europe, and Latin
America in order to provide an opportunity to share their
recent findings and discuss the challenges encountered within
each country. The major goals of the roundtable were to
evaluate HIV-associated neurocognitive impairment and determine
if it may be directly attributable to distinct HIV
subtypes or clades and to discuss the future priorities for
global NeuroAIDS research. At the Global NeuroAIDS Roundtable, presentations of preliminary research indicated
that HIV-associated neurocognitive impairment is prevalent
in all countries examined regardless of which HIV clade is
present in the region. The only clear-cut difference between
HIV-1 clades was in relation to subtypes A and D in Uganda.
However, a key point that emerged from the discussions was
that there is an urgent need to standardize neurocognitive
assessment methodologies across the globe before definitive
conclusions can be drawn regarding the relationship between
HIV clade diversity and neuropathogenesis. Future research
directions were also discussed at the roundtable with particular
emphasis on the potential of viral and host factor molecular
interactions to impact the pathophysiology of HIVassociated
neurocognitive disorders (HAND) from a global
perspective. |
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