| Publication Abstract Display | | Type: Published Abstract | | Title: Longitudinal changes in regional brain structures in groups with HIV and methamphetamine dependence. | | Authors: Archibald SL, Fennema-Notestine C, Notestine RJ, Starkey LJ, Gamst AC, Grant I, Jernigan TL | | Year: 2004 | | Publication: Society for Neuroscience Abstracts | | Volume: 14 Issue: Pages: 448 | | Abstract:In previous MR morphometry studies examining the effects of HIV and methamphetamine dependence (METH), we have demonstrated volume loss related to HIV in overall cerebral and cerebellar white matter, cortical, limbic and striatal regions. In contrast, METH was associated with larger volumes in striatal and parietal cortex relative to controls. The patterns of change for HIV and METH are distinct but overlapping. In individuals with both HIV and METH, the effects are less clear due to these opposing findings. The present study examined the longitudinal regional brain changes in two groups with a history of METH, with and without HIV, to examine the progressive nature of these disorders. Participants were abstinent at the time of imaging and received two MR exams with an average interval of 24 months (sd=10). New methods leveraged baseline anatomical information to facilitate processing of longitudinal scans. Rates of change were computed for each region. Preliminary results show regional patterns of volume loss that differ between the groups. In the METH group with HIV there is significant volume loss in the overall cortex, including temporal, frontal, occipital, and parietal lobes, and in subcortical regions, including the nucleus accumbens, lenticular nucleus, basomesial region, and caudate nucleus. There was not a significant change in white matter volume. In the METH group without HIV there were significant volume decrements in the frontal cortex, thalamus, lenticular nucleus, and basomesial region. Parietal lobe and nucleus accumbens volume loss approached significance. These findings suggest that larger volumes in METH may be reduced with time, although the effects of HIV represent a more global deterioration. |
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