Publication Abstract Display
Type: Published Abstract
Title: Neuropathological correlates of in-vivo and post-mortem structural MRI volumes in subjects with HIV.
Authors: Archibald S, Fennema-Notestine C, Masliah E, Jernigan T, Ellis R, Grant I, and the HNRC Group
Year: 1998
Publication: Society for Neuroscience Annual Meeting
Volume: Issue: Pages:
Abstract:Quantitative anatomical analysis was used to examine MRIs from 15 HIV positive subjects who died within one year of their MR examinations. The MRI measures from these HIV+ subjects were compared to those from 10 seronegative controls and to autopsy results. Anatomical abnormalities observed in the HIV+ relative to the HIV- subjects included: Decreased cerebral white matter, increased volume of white matter with abnormally elevated signal, and increased ventricular and subarachnoid CSF volumes. Both white matter reductions and elevated white matter signal appeared to be evenly distributed throughout the cerebral lobes. At autopsy of the 15 AIDS subjects, 4 were classified as having HIV encephalopathy (HIVE), 3 as CMV encephalopathy (CMVE), and 8 were considered normal (without any other CNS opportunistic infections or encephalopathy on microscopic examination). While all three groups demonstrated increased fluid and decreased white matter volumes, only the HIVE subjects demonstrated significantly elevated signal areas in the white matter. Microscopic evidence of vacuolar myelopathy was present in 6 subjects (3 HIVE cases, 2 CMVE cases and one case with o abnormality). Subjects with vacuolar myelopathy had decreased white matter volume, increased ventricular volume, and decreased overall gray matter volume compared to those without.

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