Publication Abstract Display
Type: Published Abstract
Title: Leptin and neuropsychological performance: A new biomarker for cognitive function.
Authors: Huang J, Letendre S, Marquie-Beck J, Cherner M, Kolakowski S, Ellis R, and the HNRC Group
Year: 2006
Publication: 13th Annual Conference on Retroviruses and Opportunistic Infections
Volume: Session 20 Issue: Pages: 73
Abstract:Background: Neurocognitive deficits are common in HIV infection and are reported to occur in 55-75% of HIV-infected individuals. Compared to cognitively intact HIV+ persons, impaired HIV+ individuals have a lower quality of life, are more likely to be unemployed, have greater difficulty with activities of daily living, and die early. HNCI often persists despite highly active antiretroviral therapy (HAART). New avenues of investigation are thus needed to identify novel targets of therapy. Method: Cross-sectional evaluation of blood and CSF leptin levels in 42 HIV-infected men and 42 HIV-negative controls. Subjects selected from patient population at the HIV Neurobehavioral Research Center (Simultaneous serum and CSF available; Concurrent Performance of NP testing) Results: Regression Models did not demonstrate significant associations between either CSF leptin or CSF to Serum leptin ratios and verbal and attention clinical rating scores. Conclusions: Data demonstrate an association between CSF leptin status and memory and learning function. Suggests that CSF leptin may be the mediator of previously described associations between nutritional and/or body composition status and neurocognitive performance. May provide initial evidence supporting the use of CSF leptin measures as biomarkers of neurocognitive function.

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