| Publication Abstract Display | | Type: Published Abstract | | Title: CSF pleocytosis is associated with viral trafficking from blood into CNS. | | Authors: Shao H, Smith D, Moreno J, Letendre S, Jordan P, Wong J, Ignacio C, Richman D, Frost S, Ellis R | | Year: 2006 | | Publication: 13th Annual Conference on Retroviruses and Opportunistic Infections | | Volume: Session 67 Issue: Pages: 331 | | Abstract:"BACKGROUND: HIV-1 invades the central nervous system (CNS) early after infection and evolves independently within the CNS compartment. Previous studies comparing HIV isolates from plasma and cerebrospinal fluid (CSF) have demonstrated variable compartmentalization of CSF isolates. However, few studies have characterized dynamic virologic interactions between blood and CSF. Pleocytosis, which is believed to represent inflammatory cell trafficking into CSF from blood, is common in HIV infection. We hypothesized that during the development of pleocytosis, trafficking of HIV-infected lymphocytes into CSF from extra-neural sources would result in equilibration of sequences derived from CSF and blood. |
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