| Publication Abstract Display | | Type: Published Abstract | | Title: Cytochrome P450 2D6 phenotype and methamphetamine-associated cognitive impairment. | | Authors: Cherner M, Bousman C, Barron D, Letendre S, Everall I, Heaton R, Atkinson J, Grant I | | Year: 2008 | | Publication: Journal of the International Neuropsychological Society | | Volume: 14 Issue: Suppl. 2 Pages: 130 | | Abstract:Methamphetamine(meth) dependence has been associated with
Neuropsychological impairments that are often unrelated to meth exposure
parameters such as length of abstinence, lifetime consumption, chronicity,
mode of delivery,etc.,suggesting individual differences in vulnerability to
the neurotoxic effects of meth. We examined whether vulnerability to cog-
nitive impairmentis linked to polymorphisms of liver enzyme cytochrome
P4502D6(CYP2D6), which is responsible for oxidative metabolism of meth. |
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