| Publication Abstract Display | | Type: Poster | | Title: Family history of dementia may increase risk for neuropsychological impairment among HIV infected persons. | | Authors: Moore DJ, Moseley S, McCutchan JA, Marquie-Beck JA, Frankiln DR, Vaida F, Achim C, Grant I, the CHARTER Group, the HNRC Group | | Date: 2010 | | Abstract:We examined neuropsychological (NP) ability in HIV+
persons with (n=190) and without (n=916) self-reported FHD
• Assessments were conducted at 6 academic medical centers
participating in the multi-site CHARTER study of HIVassociated
neurocognitive disorders (HAND).
• We captured FHD using a free-response self-report question;
only first-degree relatives (26%) and second-degree relatives
(74%) with FHD were considered
• NP performance was evaluated with a comprehensive NP
battery covering 7 NP domains: Verbal fluency, executive
functions, speed of information processing, learning, recall,
working memory and motor skills
• Raw NP scores were converted to demographically-adjusted
(age, education, gender) T-scores, and summarized into
deficit scores that place an emphasis on impaired NP
performance; both domain deficit scores (DDS) and a global
deficit score (GDS) were calculated
• Deficit scores range from 0 to 5 with >= 0.5 indicative of
impairment
Family History of Dementia May Increase Risk for Neuropsychological
Impairment Among HIV Infected Persons
Conclusions
• FHD may be a risk factor for the development of HAND.
Additional studies are needed to examine the mechanism(s)
and to determine whether a FHD may accelerate NP
impairment among HIV+ persons.
• The lack of a standardized instrument to assess FHD was a
significant limiation of the present study.
• Future studies using comprehensive FHD assessment
instruments combined with genotyping for neurodegeneratvie
disorders should be applied. |
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