| Publication Abstract Display | | Type: Published Abstract | | Title: Event-based prospective memory in older adults with HIV infection. | | Authors: Woods SP, Dawson M, Weber E, Grant I, and the HNRC Group | | Year: 2010 | | Publication: Journal of the International Neuropsychological Society | | Volume: 16 Issue: S1 Pages: 112 | | Abstract:Objective: Aging and HIV disease are each independently associated
with deficits in the strategic aspects of prospective memory (ProM). Considering
the growing number of older adults living with HIV infection,
the present study evaluated the combined effects of HIV and aging on
event-based ProM impairment.
Participants and Methods: One hundred and eighteen participants
were classified into one of four groups based on their HIV serostatus and
age (i.e., < 40 years and > 50 years).
Results: A series of Jonckheere-Terpstra tests revealed significant additive
effects on event-based ProMin the expected direction (ps < .001), with
the greatest deficits apparent in the older HIV+ cohort. Follow-up regression
analyses demonstrated that these between-group effects were not better
explained by other demographic factors and potential medical, and
psychiatric confounds. The additive effects of HIV and aging were most
apparent on trials for which the retrieval cue and intention were not semantically
related. In the older HIV+ cohort, performance on the semantically
unrelated ProM trials was associated with executive dysfunction,
older age, and lower nadir CD4 counts in the older HIV+ cohort.
Conclusions: Findings from this study suggest that older adults with
HIV disease may experience particular difficulty with the strategic encoding
and retrieval aspects of ProM, particularly when the cue is semantically
unrelated to the intended action, which may be related to the
neuropathological effects of these risk factors in prefrontostriatal systems
that are known to underlie ProM functioning. |
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