| Publication Abstract Display | | Type: Poster | | Title: Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV+ individuals. | | Authors: Lin K, Taylor MJ, Heaton RK, Franklin D, Jernigan TL, Fennema-Notestine C, McCutchan A, Atkinson JH, McArthur J, Morgello Simpson D, Collier A, Marra C, Gelman B, Clifford D, Grant I, for the CHARTER Group | | Date: 02-03-2010 | | Abstract:We explored the possible augmenting effect of history of traumatic brain injury (TBI) on HIV associated neurocognitive complications. HIV infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were matched for relevant demographic and HIV associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, an accepted marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder symptoms. |
return to publications listing
|