| Publication Abstract Display | | Type: Published Abstract | | Title: Prevalence of subclinical neuropathy in a cohort of neurologically asymptomatic HIV infected subjects. | | Authors: Mehta P, Kalmijn JA, Gulevich SJ, Thal LJ, Wallace M, Grant I, and the HNRC Group | | Year: 1993 | | Publication: Canadian Journal of Neurological Sciences | | Volume: 20 Issue: S4 Pages: S57 | | Abstract:To determine the prevalence of peripheral nerve abnormalities by Nerve conduction studies at different stages of HIV infection, we performed Nerve Conduction studies (NCS) on the right upper and lower extremities of 102 HIV- controls, 332 asymptomatics (CDC stages II, III, IVc2) and 79 symptomatic "other" CDC stage IV subjects. Those receiving ddI/ddC, or with a significant history of ETOH use and those with clinical neuropathy were excluded. The means of nerve conduction velocities and lat responses of each group were compared to controls using ANOVA with a post-hoc analysis to determine which group contributed to the overall difference. Prevalence of abnormalities was compared across groups using Chi-square test. Abnormal NCS's were found in 2/102 (2%) controls, 15/332 (5%) of asymptomatic subjects and 22/79 (28%) of the "other IV" group. No significant differences were found between group means of controls and asymptomatics. In contrast, group means of symptomatic (other IV) subjects were significantly slower than controls and asymptomatics (II, III, IVc2). We conclude that subclinical HIV-related peripheral neuropathy as detected by NCS, even by the most conservative estimates, is common in the more advanced CDC stages, occurring in 28% of those with ARC/AIDS (other IV), but uncommon in the asymptomatic (II, III, IVc2) subjects. |
return to publications listing
|