| Publication Abstract Display | | Type: Published Abstract | | Title: A comparison of prospective memory capacity in Huntington's Disease and HIV infection. | | Authors: Sheppard D, Woods S, Doyle K, Holden H, Turk E, Tierney S, Gilbert P | | Year: 2015 | | Publication: 43rd Annual Meeting of the International Neuropsychological Society | | Volume: Issue: Pages: | | Abstract:Objective: HIV infection is associated with deficits in the strategic aspects of prospective memory (PM), which are hypothesized to reflect prefrontostriatal circuit dysregulation. The present study evaluated this hypothesis by comparing the PM profiles of HIV infection and Huntington’s disease (HD), which is a prototypical subcortical disease.
Participants and Methods: Participants included 20 individuals diagnosed with mild-moderate HD, 80 persons infected with HIV, and 34 healthy adults. All participants completed the Memory for Intentions Screening Test (MIST), which includes 2- and 15-minute delay scales for both time- and event-based PM.
Results: A mixed effects model with gender as the covariate revealed main effects of group and PM cue, as well as a significant group by PM cue interaction (ps<.05). Planned post-hoc analyses showed no between-groups differences on the least strategically demanding 2-minute delay event-based scale. However, both HD and HIV+ groups performed below healthy adults on the more strategically demanding 2- and 15-minute time-based condition scales (ps<.05). On the 15-minute delay event-based scale, only the HIV+ group performed below the healthy adults, who did not differ from the HD group.
Conclusions: Consistent with the study’s hypotheses, both HIV and HD were associated with deficits in strategically demanding time-based PM. However, the finding that only HIV was associated with long-delay event-based PM deficits suggests that HIV+ individuals may be impaired in their capacity to retain event cue-intention pairings. Such long-delay event-based PM deficits may reflect increased retrospective memory load exacerbated by extended monitoring and retention demands, perhaps indicating greater medial temporal lobe dysfunction in HIV. |
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