| Publication Abstract Display | | Type: Poster | | Title: Moderate physical activity is associated with better neurocognitive and everyday functioning in older adults with HIV disease. | | Authors: Fazeli P, Marquine MJ, Dufour C, Henry BL, Montoya J, Gouaux, B, Moore R, Letendre SL, Woods SP, Grant I, Jeste D, Moore DJ, and the HNRP Group | | Date: 02-04-2015 | | Abstract:Purpose: The current study examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. Methods: One hundred older (≥50 years) HIV+ adults completed the International Physical Activity Questionnaire (IPAQ) to assess frequency, duration, and intensity of PA over the previous week. Global and domain-specific NCI was determined with a comprehensive battery. Participants were classified as IADL Dependent or Independent using a modified Lawton and Brody ADL scale. Results: Higher levels of moderate PA were associated with lower odds of global NCI (p=0.01), even when relevant covariates were modeled. Examination of domain-specific NCI revealed the association between moderate PA and global NCI was driven by executive function (p=0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p=0.03), although this relationship fell to the trend level (p=0.08) when including relevant covariates. Lastly, a follow-up analysis showed that those with both NCI and IADL Dependence had lower moderate PA than those with neither condition (p=0.03). Conclusions: These cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning among older HIV+ adults. Previous studies have shown that PA can promote neurogenesis and reduce NCI risk factors, such as metabolic and cardiovascular comorbidities among older HIV-uninfected adults. Longitudinal studies with older HIV+ persons utilizing objective PA methods are needed to more precisely evaluate: 1) the directionality of the association between PA, NCI, and everyday functioning, and 2) the underlying mechanisms of these associations. |
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