| Publication Abstract Display | | Type: Published Abstract | | Title: Living situation is associated with antiretroviral dose timing among persons with HIV and Bipolar disorder. | | Authors: Montoya JL, Blackstone K, Gouaux B, Poquette A, Rooney A, Depp C, Grant I, Atkinson JH, Moore DJ | | Year: 2014 | | Publication: Society of Behavioral Medicine | | Volume: Issue: Pages: | | Abstract:Objective: Persons living with HIV and bipolar disorder (HIV/BD) evidence poor adherence to antiretroviral (ARV) therapy, which is associated with psychosocial variables such as environmental social support. The present study evaluated the efficacy of an individualized texting for adherence building (iTAB) intervention to improve ARV adherence in the context of living situation (e.g., living alone vs. with others).
Methods: ARV medications of 49 HIV/BD participants were tracked for 30 days using electronic Medication Event Monitoring Systems. Participants were randomized to iTAB (n=25) or an active comparison intervention (CTRL; n=24). Both groups received psychoeducation and a daily text message to track mood; the iTAB group also received personalized medication reminder texts. Dose timing (i.e., mean absolute value of time from planned dose time) was calculated.
Results: Demographic, psychiatric, neurocognitive, and living arrangement variables did not differ by treatment arm (p>.05). A multivariable model including treatment arm (iTAB vs. CTRL), current living situation (alone vs. with others), and the interaction between these factors accounted for 11% of the variance in ARV dose timing (p<.05). The interaction was significant (p=.02), such that iTAB participants who lived with others achieved better ARV dose timing (M=69 mins from target dose time) compared to iTAB participants who lived alone (M=138 mins) and CTRL participants who lived with others (M=184 mins).
Conclusions: External social support appears to impact the efficacy of a text messaging intervention by additively improving ARV dose timing for HIV/BD persons living with others. Living with others without receiving reminder texts resulted in poorer ARV dose timing. Future texting interventions targeting those with less stable social support may be warranted in order to reach comparable therapeutic outcomes. |
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