| Publication Abstract Display | | Type: Poster | | Title: Verbal learning and memory profiles in HIV-associated neurocognitive disorders: A comparison with Huntington's Disease and Temporal Lobe Epilepsy. | | Authors: Doyle KL, Woods SP, McDonald C, Leyden K, Holden H, Morgan EE, Gilbert PE, and the HNRP Group | | Date: 02-03-2016 | | Abstract:Findings from this study are consistent with a subcortical vs. cortical pattern of HIV-associated verbal episodic memory impairment.
HAND was associated with a greater proportion of retrieval deficit profiles than encoding deficit profiles, consistent with the primary frontostriatal neuropathogenesis of HIV disease.
While all clinical groups showed expected directions of retrieval vs. encoding deficit profiles, there was significant heterogeneity of memory profiles across all groups, even in traditional subcortical vs. cortical disorders.
Examination of performance on CVLT-II primary measures also showed unexpected patterns across clinical groups.
Future studies may wish to investigate is this heterogeneity, which may reflect neuropathological variability, measurement error, and/or the influence of secondary variables (e.g., cognitive and brain reserve) in these populations. |
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